Maintenance Chemotherapy in Patients With High-Risk Rhabdomyosarcoma: Long-Term Survival Analysis of the European Paediatric Soft Tissue Sarcoma Study Group RMS
2005 Trial
Gianni Bisogno, Julia Chisholm, Raquel Hladun, Gian Luca De Salvo, Florent Guerin, Michela Casanova, Henry Mandeville, Rita Alaggio, Beatrice Coppadoro, Daniel Orbach, Andrea Ferrari, Rick van Rijn, Anne-Sophie Defachelles, Myriam Ben-Arush, Heidi Glosli, Maja Cesen, Johannes H.M. Merks and Veronique Minard-Colin. J Clin Oncol. 2025 Mar 7:JCO2402850. doi: 10.1200/JCO-24-02850. Online ahead of print.PMID: 40053891
The RMS2005 trial, conducted by the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG),…
Implications of Implementing Children's Oncology Group Risk Stratification to Patients With Rhabdomyosarcoma Treated on European Paediatric Soft Tissue Sarcoma Study Group Clinical Trial.
Bisogno G, Minard-Colin V, Haduong J, Zanetti I, Ferrari A, Chisholm J, Heske CM, Hladun R, Jenney M, Merks JHM, Venkatramani R.
Pediatr Blood Cancer. 2025 Feb;72(2):e31436. doi: 10.1002/pbc.31436. Epub 2024 Nov 20.
PMID: 39568171
Rhabdomyosarcoma (RMS) is a type of cancer that primarily affects children, and determining the…
Maintenance therapy for pediatric patients with high-risk Rhabdomyosarcoma: A report of dose reductions and dose omissions on outcome.
Daniela Di Carlo, Lisa Lyngsie Hjalgrim, Beatrice Coppadoro, Michela Casanova , Andrea Ferrari, Veronique Minard-Colin , Hans Merks , Gianni Bisogno, EJC Paediatric Oncology. Volume 5, June 2025, 100221
A clinical trial called RMS2005 studied whether adding a lower-dose, long-term chemotherapy…
Parameningeal Rhabdomyosarcoma: Results of the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 Study.
Schoot RA, Taselaar P, Scarzello G, Kolb F, Coppadoro B, Horst ST, Mandeville H, Ferrari A, Hladun R, Helfre S, Ferman S, Kelsey A, Hol MLF, Devalck C, Ben-Arush M, Orbach D, Chisholm J, Jenney M, Minard-Colin V, Bisogno G, Merks JHM.
Head Neck. 2024 Nov 15. doi: 10.1002/hed.27994. Online ahead of print.
PMID: 39545397
The parameningeal (PM) localization is a known adverse prognostic factor in rhabdomyosarcoma (RMS)…
Prognostic role of bone erosion in orbital RMS: a report from the European Pediatric Soft Tissue Sarcoma Study Group (EpSSG).
Di Carlo D, Fichera G, Minard-Colin V, Coppadoro B, Orbach D, Cameron A, Albiac Ramos M, Ben Arush M, Merks JHM, Bisogno G.
Front Oncol. 2024 Dec 12;14:1497193. doi: 10.3389/fonc.2024.1497193. eCollection 2024.
PMID: 39726711
Orbital rhabdomyosarcoma (RMS) typically remains confined to the orbital cavity and has a favorable…
Localized incompletely resected standard risk rhabdomyosarcoma in children and adolescents: Results from the European Paediatric Soft Tissue Sarcoma Study Group RMS 2005 trial.
Mandeville HC, Bisogno G, Minard-Colin V, Alaggio R, Ben-Arush M, Chargari C, Coppadoro B, Craigie R, Devalck C, Ferman S, Ferrari A, Glosli H, Alvaro RH, Hol M, Mudry P, Orbach D, Albiac MR, Merks JHM, Jenney MEM.Cancer. 2024 Jul 26. doi: 10.1002/cncr.35497. Online ahead of print.PMID: 39058728
This study evaluated the outcomes of children and young people with localised rhabdomyosarcoma…
Treatment of Pediatric, Adolescent, and Young Adult Patients With Fusion-Positive Alveolar Rhabdomyosarcoma Infiltrating Regional Lymph Nodes in the European CWS-2002P and RMS 2005 Studies and the Soft Tissue Sarcoma Registry.
Heinz AT, Ciuffolotti M, Merks JHM, Schönstein A, Minard-Colin V, Fuchs J, Guillen G, Timmermann B, Vokuhl C, Koscielniak E, Chisholm JC, Sparber-Sauer M, Bisogno G.
Pediatr Blood Cancer. 2024 Dec 10:e31476. doi: 10.1002/pbc.31476. Online ahead of print.
PMID: 39655886
Alveolar rhabdomyosarcoma (ARMS) is a rare and aggressive cancer, particularly when it spreads to…
Reappraisal of prognostic factors used in the European Pediatric Soft Tissue Sarcoma Study Group RMS 2005 study for localized rhabdomyosarcoma to optimize risk stratification and generate a prognostic nomogram.
De Salvo GL, Del Bianco P, Minard-Colin V, Chisholm J, Jenney M, Guillen G, Devalck C, Van Rijn R, Shipley J, Orbach D, Kelsey A, Rogers T, Guerin F, Scarzello G, Ferrari A, Cesen Mazic M, Merks JHM, Bisogno G; European Pediatric Soft Tissue Sarcoma Study Group.Cancer. 2024 Jul 1;130(13):2351-2360. doi: 10.1002/cncr.35258. Epub 2024 Feb 24.PMID: 38400828
This study used data from patients enrolled in the EpSSG RMS 2005 study to investigate the role of…
The Impact of Radiation Therapy on Metastatic Rhabdomyosarcoma: Results From the EpSSG MTS 2008 Study
Cameron AL, Mandeville H, Coppadoro B, Periasamy M, Davila Fajardo R, Ferrari A, Gaze MN, Helfre S, Magelssen H, Minard-Colin V, Ramos M, Schoot R, Zanetti I, Bisogno G, Chisholm JC, Merks JHM.
Int J Radiat Oncol Biol Phys. 2024 Sep 1:S0360-3016(24)03318-2. doi: 10.1016/j.ijrobp.2024.08.039. Online ahead of print. PMID: 39222824
Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines.
Dávila Fajardo R, Scarzello G, Gaze MN, Boterberg T, Cameron A, Fuchs J, Guérin F, Hoskin P, Krasin MJ, Kroon P, Magelssen H, Mercke C, Merks JHM, Paulsen F, Pommier P, Ramos M, Rees H, Rogers T, Schmid M, Seitz G, Slater O, Smeulders N, Stenman J, Terwisscha S, Chargari C, Mandeville HC. Radiother Oncol. 2024 Jun;195:110273. doi: 10.1016/j.radonc.2024.110273. Epub 2024 Apr 7.
Indeterminate pulmonary nodules in non‐rhabdomyosarcoma soft tissue sarcoma: A study of the European paediatric Soft Tissue Sarcoma Study Group.
Giraudo C, Schoot R, Cardoen L, Stramare R, Coppadoro B, Bisogno G, Bouhamama A, Brennan B, Brisse HJ, Orbach D, Coma A, Di Paolo PL, Fayard C, McDonald L, Moalla S, Morosi C, Pace E, Tang V, van Noesel M, Ferrari A, van Rijn R. Cancer 2023 Oct 17. doi: 10.1002/cncr.35061. Online ahead of print.
Radiologists should be aware of the classification of indeterminate pulmonary nodules in…
Frontline and Relapsed Rhabdomyosarcoma (FAR-RMS) Clinical Trial: A Report from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG).
Chisholm J, Mandeville H, Adams M, Minard-Collin V, Rogers T, Kelsey A, Shipley J, van Rijn RR, de Vries I, van Ewijk R, de Keizer B, Gatz SA, Casanova M, Hjalgrim LL, Firth C, Wheatley K, Kearns P, Liu W, Kirkham A, Rees H, Bisogno G, Wasti A, Wakeling S, Heenen D, Tweddle DA, Merks JHM, Jenney M.Cancers (Basel). 2024 Feb 29;16(5):998. doi: 10.3390/cancers16050998.PMID: 38473359
This review article describes the rationale, design and study questions of the international EpSSG…
Quantitative diffusion-weighted MRI response assessment in rhabdomyosarcoma: an international retrospective study on behalf of the European paediatric Soft tissue sarcoma Study Group Imaging Committee.
van Ewijk R, Chatziantoniou C, Adams M, Bertolini P, Bisogno G, Bouhamama A, Caro-Dominguez P, Charon V, Coma A, Dandis R, Devalck C, De Donno G, Ferrari A, Fiocco M, Gallego S, Giraudo C, Glosli H, Ter Horst SAJ, Jenney M, Klein WM, Leemans A, Leseur J, Mandeville HC, McHugh K, Merks JHM, Minard-Colin V, Moalla S, Morosi C, Orbach D, Ording Muller LS, Pace E, Di Paolo PL, Perruccio K, Quaglietta L, Renard M, van Rijn RR, Ruggiero A, Sirvent SI, De Luca A, Schoot RA. Pediatr Radiol. 2023 Nov;53(12):2539-2551. doi: 10.1007/s00247-023-05745-z. Epub 2023 Sep 8.PMID: 37682330
Biological Role and Clinical Implications of MYOD1L122R Mutation in Rhabdomyosarcoma.
Di Carlo D, Chisholm J, Kelsey A, Alaggio R, Bisogno G, Minard-Colin V, Jenney M, Dávila Fajardo R, Merks JHM, Shipley JM, Selfe JL
Recent advances have greatly improved our understanding of rhabdomyosarcoma (RMS), a type of cancer,…
Maintenance Chemotherapy for Patients with Rhabdomyosarcoma
Bisogno G, Minard-Colin V, Jenney M, Ferrari A, Chisholm J, Di Carlo D, Hjalgrim LL, Orbach D, Merks JHM, Casanova M. Cancers (Basel). 2023 Aug 7;15(15):4012. doi: 10.3390/cancers15154012.
The updated results of the RMS2005 randomized study confirm that patients with non-metastatic high…
Outcomes in lung-only metastatic rhabdomyosarcoma: An analysis of data from the European paediatric Soft tissue sarcoma Study Group MTS 2008 study
Chisholm JC, Schoot RA, Cameron AL, Casanova M, Minard-Colin V, Coppadoro B, Garrido B, Rogers B, Orbach D, Glosli H, Ben-Arush M, Ferman S, Scarzello G, van Rijn RR, Hladun R, Corradini N, Ferrari A, Jenney M, Bisogno G, Merks JHM. EJC 2023. https://doi.org/10.1016/j.ejcped.2023.100018
Among patients with metastatic rhabdomyosarcoma, outcomes are better in patients for whom lung is…
Time to broaden the eligibility criteria in paediatric oncology trials? An analysis of patients with rhabdomyosarcoma non-eligible to the EpSSG RMS2005 trial
Bisogno G, De Salvo GL, Minard-Colin V, Davila Fajardo R, Coppadoro B, Jenney M, Ferrari A, Hladun Alvaro R, Dall’Igna P, Glosli H, Merks JHM. EJC. 2023 May doi: https://doi.org/10.1016/j.ejcped.2023.100014
Clinical trials for pediatric rhabdomyosarcoma (RMS) include specific rules to ensure patient safety…
Outcome of patients with undifferentiated embryonal sarcoma of the liver treated according to European soft tissue sarcoma protocols
Guérin F, Martelli H, Rogers T, Zanetti I, Terwisscha van Scheltinga S, De Corti F, Guillen Burrieza G, Minard-Colin V, Orbach D, van Noesel MM, Karanian M, Dávila Fajardo R, Merks JHM, Ferrari A, Bisogno G, Pediatr Blood Cancer. 2023 Jul;70(7):e30374. doi: 10.1002/pbc.30374. Epub 2023 Apr 21.
Highlights of the paper: Neoadjuvant chemotherapy for pediatric patients with UESL increases the…
Nonmetastatic Rhabdomyosarcoma in Children and Adolescents: Overall Results of the European Pediatric Soft Tissue Sarcoma Study Group RMS2005 Study
Bisogno G, Minard-Colin V, Zanetti I, Ferrari A, Gallego S, Davila Fajardo R, Mandeville H, Kelsey A, Alaggio R, Orbach D, Terwisscha van Scheltinga S, Guillen Burrieza G, Ben-Arush M, Glosli H, Mudry P, Ferman S, Devalck C, Defachelles AS, Merks JHM, Jenney M.
J Clin Oncol 2023 May 1;41(13):2342-2349.doi: 10.1200/JCO.22.02093. Epub 2023 Feb 27.
The study was open from October 1st, 2005, to December 31st, 2016 and 1,733 patients were enrolled…
Intra-abdominal desmoplastic small round cell tumor: The European pediatric Soft tissue sarcoma Study Group (EpSSG) experience.
Berlanga P, Orbach D, Schoot RA, Casanova M, Alaggio R, Corradini N, Brennan B, Ramirez-Villar GL, Hjalgrim L, Chisholm J, Bisogno G, Coppadoro B, Safwat A, Merks JHM, Guillen Burrieza G, van Noesel MM, Ferrari A.Pediatr Blood Cancer 2023 May 26;e30447. doi: 10.1002/pbc.30447.
Desmoplastic small round cell tumor (DSRCT) is an ultra-rare and aggressive mesenchymal tumor…
